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PROTOCOL 06 // TOXICOLOGY & DRUGS

Forensic Toxicology & Chemical Analysis

CALIBRATING EVIDENCE SENSORS...

INFINITE FORENSICS
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DOSSIER #IF-DOM-06
PROTOCOL 06 // TOXICOLOGY & DRUGS

Forensic Toxicology & Chemical Analysis

Xenobiotic Isolation, Gas Chromatography-Mass Spectrometry & Poison Quantification

"Poisons whisper in microscopic tissues; mass spectrometry makes them confess."

The isolation, qualitative identification, and quantitative analysis of drugs of abuse, therapeutic pharmaceuticals, volatile compounds, heavy metals, and lethal agricultural poisons in biological fluids and post-mortem organs.

CORE INTELLIGENCE
VERIFIED SYLLABUS
EXHIBIT CODE:IF-DISC-006
PRIMARY PROTOCOL:Section 45 IEA / BSA Standards
INSTRUMENT TIME:Active Bench Casework
INDUSTRY OUTLOOK:High Vocational Demand
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CORE FORENSIC PRINCIPLE

Foundational Admissibility Law

Dose Determines the Poison (Paracelsus): Every substance can be toxic depending on concentration, metabolic rate, route of administration, and post-mortem redistribution.

Judicial Standing: Decisive in establishing whether poisoning, drug overdose, or intoxication was the proximate or contributory cause of death in medico-legal autopsies.
SCIENTIFIC & EMPIRICAL BASIS

Analytical Methodology

Liquid-liquid or solid-phase extraction followed by high-resolution chromatographic separation (GC/HPLC) and 70 eV electron impact fragmentation creating molecular mass fingerprints.

  • Solid-phase extraction (SPE) with C18 silica column cartridges
  • Helium carrier gas chromatographic oven temperature ramps
  • NIST / Wiley mass spectral fragmentation library cross-matching
STANDARD OPERATING CASWORK WORKFLOW

How An Examiner Investigates This Evidence

From scene cordoning to laboratory instrumentation and final deposition.

01STAGE 01

Solid-Phase Biological Extraction (SPE)

Purify targeted chemical compounds from gastric aspirates, blood, and liver tissues to avoid instrument column fouling.

02STAGE 02

Gas Chromatographic Separation

Separate volatile chemical mixtures along a 30-meter capillary column to measure characteristic retention times.

03STAGE 03

Electron Impact Mass Spectrometry (GC-MS)

Shatter molecules at 70 eV into diagnostic ionized fragments (m/z) and match against NIST reference databases.

Primary Laboratory Instruments & Software

Official instrumentation deployed across accredited FSLs & independent crime labs.

1Gas Chromatography-Mass Spectrometry (GC-MS / Agilent 7890B-5977B)
2Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
3Inductively Coupled Plasma Mass Spectrometry (ICP-MS for heavy metals)
4Fourier-Transform Infrared Spectrometer (FTIR)
5UV-Visible Double Beam Spectrophotometers
EVIDENCE VAULT EXPLORATION

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Forensic Toxicology & Chemical Analysis
Xenobiotic Isolation, Gas Chromatography-Mass Spectrometry & Poison Quantification
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